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Imaging Updates

PFI Resource Center

Welcome to the Imaging Updates Section of Prostascintimaging.com

In this area you will find information that should enhance your ProstaScint® Fusion Imaging experience.

ProstaScint Overreads:

If you utilize the ProstaScint Overread Service, please note the following:

Make sure that all patient identifiers are removed from images before sending in for an overread. Please remember to include the whole body dataset as well as the SPECT images.

The overreader will not return the datasets sent to them so make sure an original set is kept in the department.

Please remember that the overreader will provide educational input 24 to 48 hours after they receive the image data.

The overreaders request that image data be sent on CD in DICOM format and include a CT or MRI if at all possible.

ProstaScint Imaging Technique:

The following are suggestions to consider when performing a ProstaScint study. These recommendations came from physicians who participate in the Cytogen Overread Program and have extensive experience in ProstaScint imaging:

Cathartics:
Golytely, Nulytely, or Mag Citrate (may cause inflammation) the evening prior to imaging should be considered to cleanse the antibody excretory pathway If bowel activity persists, consider additional delayed images to evaluate further.

Technologist is paramount to a good ProstaScint study:
Proper acquisition, processing and fusion are critical to good studies that provide solid interpretative results. The technologist is the key to this component.

Imaging parameters:
Optimal imaging time is 96→120 hours. Imaging on day 5 or 120 hours provides additional time for the antibody to clear from the blood pool which can create image data that has better target to background ratios than with earlier delayed imaging.

Imaging protocol considerations:
When imaging ProstaScint some form of blood pool image is recommended to evaluate the blood vessels and determine if uptake on delayed imaging is nodal versus vascular. In order to accomplish this task, consider one of the following protocols:

Day 0
Blood Pool
Day 4/5
Delay
CT/MRI
With or W/O contrast
 
Day 0
None
Day 4/5
Delay + Blood Pool
CT/MRI
With or W/O contrast
 
Day 0
None
Day 4/5
Delay
CT/MRI
With Contrast

Please check this site frequently for new updates.

DISCLAIMER: Cytogen does not offer medical advice and shall not be responsible for any physicians' reliance on this information. This information is intended for general educational reference only and is not to be considered as advice being offered on behalf of Cytogen. The information is not intended to provide definitive or complete medical, instructional or treatment information. Appropriate medical care decisions shall be made by qualified healthcare professionals after appropriate evaluation of their patients' conditions with reliance on their medical education and training. Any products referenced herein should be used consistently with their package inserts and any devices referenced herein should be used in a manner consistent with the operating instructions provided by their respective manufacturers.

To view a copy of the full prescribing information for ProstaScint, click here.

Patient management should not be based on ProstaScint® scan results without appropriate confirmatory studies since in the pivotal trials, there was a high rate of false positive and false negative image interpretations. ProstaScint images should be interpreted only by physicians who have had specific training in ProstaScint image interpretation. Medications for the treatment of hypersensitivity reactions should be available during administration of this agent.

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